Antimicrobial RNases of Human Skin
نویسندگان
چکیده
منابع مشابه
Antimicrobial RNases in cutaneous defense.
Antimicrobial proteins (AMP) are small endogenous proteins which are capable of rapidly inactivating microorganisms at low micro- and nanomolar concentrations. Their significance in host defense is reflected by their wide distribution in nature. Several AMP have been isolated from human skin, and there is increasing evidence that AMP may play an important role in cutaneous defense. One importan...
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To control the growth of microorganisms on its surface, human skin produces and releases certain peptides and proteins, including cathelicidin LL-37 and β-defensins. The ribonuclease A (RNase A) superfamily is an important class in this armament (Koczera et al., 2016). This superfamily consists of 13 genes located on chromosome 14; eight of the 13 genes encode proteins (RNases 1–8) that are cat...
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The central dogma states that DNA is transcribed to generate RNA and that the mRNA components are then translated to generate proteins; a simple statement that completely belies the complexities of gene expression. Post-transcriptional regulation alone has many points of control, including changes in the stability, translatability or susceptibility to degradation of RNA species, where both cis-...
متن کاملAntimicrobial peptides and the skin.
In recent years, hundreds of naturally occurring peptide antibiotics have been discovered based on their ability to inhibit the growth of microbial pathogens. These antimicrobial peptides (AMPs) participate in the innate immune response by providing a rapid first-line defence against infection. This review discusses the biology and clinical relevance of the two major families of AMPs, cathelici...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2009
ISSN: 0022-202X
DOI: 10.1038/jid.2009.216